1z4u
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hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00799585
OverviewOverview
A novel series of non-nucleoside HCV NS5B polymerase inhibitors was, prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid, template. Solution and solid phase analog synthesis focused on the, northern region of the template combined with structure based design led, to the discovery of several potent and orally bioavailable lead compounds.
About this StructureAbout this Structure
1Z4U is a Protein complex structure of sequences from Hepatitis c virus with CL, PO4, PH9 and GOL as ligands. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
ReferenceReference
Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid., Pfefferkorn JA, Nugent R, Gross RJ, Greene M, Mitchell MA, Reding MT, Funk LA, Anderson R, Wells PA, Shelly JA, Anstadt R, Finzel BC, Harris MS, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. PMID:15911260
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