1yu0
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Major Tropism Determinant P1 Variant
OverviewOverview
Only few instances are known of protein folds that tolerate massive, sequence variation for the sake of binding diversity. The most extensively, characterized is the immunoglobulin fold. We now add to this the C-type, lectin (CLec) fold, as found in the major tropism determinant (Mtd), a, retroelement-encoded receptor-binding protein of Bordetella bacteriophage., Variation in Mtd, with its approximately 10(13) possible sequences, enables phage adaptation to Bordetella spp. Mtd is an intertwined, pyramid-shaped trimer, with variable residues organized by its CLec fold, into discrete receptor-binding sites. The CLec fold provides a highly, static scaffold for combinatorial display of variable residues, probably, reflecting a different evolutionary solution for balancing diversity, against stability from that in the immunoglobulin fold. Mtd variants are, biased toward the receptor pertactin, and there is evidence that the CLec, fold is used broadly for sequence variation by related retroelements.
About this StructureAbout this Structure
1YU0 is a Single protein structure of sequence from Bordetella phage bpp-1 with CA as ligand. Full crystallographic information is available from OCA.
ReferenceReference
The C-type lectin fold as an evolutionary solution for massive sequence variation., McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P, Nat Struct Mol Biol. 2005 Oct;12(10):886-92. Epub 2005 Sep 18. PMID:16170324
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