1qhv
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HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD
OverviewOverview
Adenovirus binds to its receptor via the head domain of its fiber protein., We have crystallized the adenovirus serotype 2 (subgroup C) receptor, binding domain and solved the structure at 1.5 A resolution by the, molecular replacement technique using the known adenovirus type 5 head, structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic, temperature factors for each atom. The overall structure of the serotype 2, head is very similar to its serotype 5 homologue, apart from differences, in some of the flexible loops. All but subgroup B adenoviruses are, believed to use the recently identified protein CAR (Coxsackievirus and, adenovirus receptor) as receptor. By comparison of the two structures and, sequence alignment of CAR binding and non-CAR binding serotype fiber, heads, we discuss possible receptor binding sites and propose a receptor, binding site in a crevice between two monomers on the side of the trimer., The structural basis of the extraordinary stability of the fiber head, trimer is also discussed.
About this StructureAbout this Structure
1QHV is a Single protein structure of sequence from Human adenovirus 2 with SO4 as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:10502512
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