8tle

CDCA7 (Mouse) Binds Non-B-form 36-mer DNA oligo (sg C2-Form 1)CDCA7 (Mouse) Binds Non-B-form 36-mer DNA oligo (sg C2-Form 1)

Structural highlights

8tle is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.08Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CDCA7_MOUSE Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity).^[1]

References

↑ Goto Y, Hayashi R, Muramatsu T, Ogawa H, Eguchi I, Oshida Y, Ohtani K, Yoshida K. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta. 2006 Jan-Feb;1759(1-2):60-8. PMID:16580749 doi:10.1016/j.bbaexp.2006.02.004

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Goto Y, Hayashi R, Muramatsu T, Ogawa H, Eguchi I, Oshida Y, Ohtani K, Yoshida K. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta. 2006 Jan-Feb;1759(1-2):60-8. PMID:16580749 doi:10.1016/j.bbaexp.2006.02.004

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