8osb

TWIST1-TCF4-ALX4 complex on specific DNATWIST1-TCF4-ALX4 complex on specific DNA

Structural highlights

8osb is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

ITF2_HUMAN Autosomal dominant non-syndromic intellectual disability;Fuchs endothelial corneal dystrophy;Pitt-Hopkins syndrome;Schizophrenia;Primary sclerosing cholangitis. The disease is caused by mutations affecting the gene represented in this entry.

Function

ITF2_HUMAN Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.

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OCA