8fw9

Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetryCryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry

Structural highlights

8fw9 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 4.46Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

NLRC4_HUMAN The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

NLRC4_HUMAN Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]^[1]

References

↑ Damiano JS, Oliveira V, Welsh K, Reed JC. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J. 2004 Jul 1;381(Pt 1):213-9. doi: 10.1042/BJ20031506. PMID:15107016 doi:http://dx.doi.org/10.1042/BJ20031506

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OCA

[1] Damiano JS, Oliveira V, Welsh K, Reed JC. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J. 2004 Jul 1;381(Pt 1):213-9. doi: 10.1042/BJ20031506. PMID:15107016 doi:http://dx.doi.org/10.1042/BJ20031506

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