7xrb

human STK19 dimerhuman STK19 dimer

Structural highlights

7xrb is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.65Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

STK19_HUMAN Inactive serine/threonine-protein kinase (Probable) (PubMed:32531245, PubMed:32531246). May control NRAS activity via an associated kinase (Probable) (PubMed:32531246).^[1] ^[2] Inactive serine/threonine-protein kinase.^[3]

References

↑ Rodríguez-Martínez M, Boissiére T, Noe Gonzalez M, Litchfield K, Mitter R, Walker J, Kjœr S, Ismail M, Downward J, Swanton C, Svejstrup JQ. Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver. Cell. 2020 Jun 11;181(6):1395-1405.e11. PMID:32531245 doi:10.1016/j.cell.2020.04.014
↑ Yin C, Zhu B, Li X, Goding CR, Cui R. A Reply to ''Evidence that STK19 Is Not an NRAS-Dependent Melanoma Driver". Cell. 2020 Jun 11;181(6):1406-1409.e2. PMID:32531246 doi:10.1016/j.cell.2020.04.029
↑ Rodríguez-Martínez M, Boissiére T, Noe Gonzalez M, Litchfield K, Mitter R, Walker J, Kjœr S, Ismail M, Downward J, Swanton C, Svejstrup JQ. Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver. Cell. 2020 Jun 11;181(6):1395-1405.e11. PMID:32531245 doi:10.1016/j.cell.2020.04.014

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OCA

[1] Rodríguez-Martínez M, Boissiére T, Noe Gonzalez M, Litchfield K, Mitter R, Walker J, Kjœr S, Ismail M, Downward J, Swanton C, Svejstrup JQ. Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver. Cell. 2020 Jun 11;181(6):1395-1405.e11. PMID:32531245 doi:10.1016/j.cell.2020.04.014

[2] Yin C, Zhu B, Li X, Goding CR, Cui R. A Reply to ''Evidence that STK19 Is Not an NRAS-Dependent Melanoma Driver". Cell. 2020 Jun 11;181(6):1406-1409.e2. PMID:32531246 doi:10.1016/j.cell.2020.04.029

[3] Rodríguez-Martínez M, Boissiére T, Noe Gonzalez M, Litchfield K, Mitter R, Walker J, Kjœr S, Ismail M, Downward J, Swanton C, Svejstrup JQ. Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver. Cell. 2020 Jun 11;181(6):1395-1405.e11. PMID:32531245 doi:10.1016/j.cell.2020.04.014

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