6o0h

Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143Cryo-EM structure of human ATP-citrate lyase in complex with inhibitor NDI-091143

6o0h, resolution 3.67Å Show:Asymmetric Unit Biological Assembly Structural highlights 6o0h is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.67Å Ligands: Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ACLY_HUMAN ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. See Also ATP-citrate synthase 3D structures