6gv3

Structure of the E2 conjugating enzyme, SCE1, from Arabidopsis thaliana.Structure of the E2 conjugating enzyme, SCE1, from Arabidopsis thaliana.

Structural highlights

6gv3 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SCE1_ARATH] SUMO-conjugating enzyme that accepts the SUMO proteins from the E1 SUMO-activating heterodimer SAE1/SAE2 and catalyzes its covalent attachment to other proteins with the E3 SUMO ligases SIZ1 and MMS21. Associates with SIZ1 for sumoylation of the transcription factor GTE3.^[1] ^[2] ^[3]

References

↑ Saracco SA, Miller MJ, Kurepa J, Vierstra RD. Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential. Plant Physiol. 2007 Sep;145(1):119-34. Epub 2007 Jul 20. PMID:17644626 doi:http://dx.doi.org/10.1104/pp.107.102285
↑ Garcia-Dominguez M, March-Diaz R, Reyes JC. The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins. J Biol Chem. 2008 Aug 1;283(31):21469-77. doi: 10.1074/jbc.M708176200. Epub 2008 , May 23. PMID:18502747 doi:http://dx.doi.org/10.1074/jbc.M708176200
↑ Huang L, Yang S, Zhang S, Liu M, Lai J, Qi Y, Shi S, Wang J, Wang Y, Xie Q, Yang C. The Arabidopsis SUMO E3 ligase AtMMS21, a homologue of NSE2/MMS21, regulates cell proliferation in the root. Plant J. 2009 Nov;60(4):666-78. Epub 2009 Aug 8. PMID:19682286 doi:http://dx.doi.org/TPJ3992

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Saracco SA, Miller MJ, Kurepa J, Vierstra RD. Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential. Plant Physiol. 2007 Sep;145(1):119-34. Epub 2007 Jul 20. PMID:17644626 doi:http://dx.doi.org/10.1104/pp.107.102285

[2] Garcia-Dominguez M, March-Diaz R, Reyes JC. The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins. J Biol Chem. 2008 Aug 1;283(31):21469-77. doi: 10.1074/jbc.M708176200. Epub 2008 , May 23. PMID:18502747 doi:http://dx.doi.org/10.1074/jbc.M708176200

[3] Huang L, Yang S, Zhang S, Liu M, Lai J, Qi Y, Shi S, Wang J, Wang Y, Xie Q, Yang C. The Arabidopsis SUMO E3 ligase AtMMS21, a homologue of NSE2/MMS21, regulates cell proliferation in the root. Plant J. 2009 Nov;60(4):666-78. Epub 2009 Aug 8. PMID:19682286 doi:http://dx.doi.org/TPJ3992

[1]

[2]

[3]