6bgi

Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodiscCryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc

6bgi, resolution 3.80Å Show:Asymmetric Unit Biological Assembly Structural highlights 6bgi is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.8Å Ligands: Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ANO1_MOUSE Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.