5jk5

Phenylalanine hydroxylase from dictyostelium - BH2 complexPhenylalanine hydroxylase from dictyostelium - BH2 complex

Structural highlights

5jk5 is a 2 chain structure with sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.071Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PH4H_DICDI Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.^[1]

References

↑ Siltberg-Liberles J, Steen IH, Svebak RM, Martinez A. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 2008 Dec 31;427(1-2):86-92. doi: 10.1016/j.gene.2008.09.005. Epub 2008 Sep , 16. PMID:18835579 doi:http://dx.doi.org/10.1016/j.gene.2008.09.005

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OCA

[1] Siltberg-Liberles J, Steen IH, Svebak RM, Martinez A. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 2008 Dec 31;427(1-2):86-92. doi: 10.1016/j.gene.2008.09.005. Epub 2008 Sep , 16. PMID:18835579 doi:http://dx.doi.org/10.1016/j.gene.2008.09.005

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