4l68

Structure of the psedudokinase domain of BIR2, an immune regulator of the RLK/Pelle familyStructure of the psedudokinase domain of BIR2, an immune regulator of the RLK/Pelle family

Structural highlights

4l68 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BIR2_ARATH Pseudokinases lacking protein kinase activity and unable to bind ATP-analogs (PubMed:24556575). Negative regulator of pathogen-associated molecular patterns- (PAMP-) triggered immunity by limiting BAK1-receptor complex formation in the absence of ligands (PubMed:24388849).^[1] ^[2]

References

↑ Halter T, Imkampe J, Mazzotta S, Wierzba M, Postel S, Bucherl C, Kiefer C, Stahl M, Chinchilla D, Wang X, Nurnberger T, Zipfel C, Clouse S, Borst JW, Boeren S, de Vries SC, Tax F, Kemmerling B. The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity. Curr Biol. 2014 Jan 20;24(2):134-43. doi: 10.1016/j.cub.2013.11.047. Epub 2014, Jan 2. PMID:24388849 doi:http://dx.doi.org/10.1016/j.cub.2013.11.047
↑ Blaum BS, Mazzotta S, Noldeke ER, Halter T, Madlung J, Kemmerling B, Stehle T. Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis. J Struct Biol. 2014 Apr;186(1):112-21. doi: 10.1016/j.jsb.2014.02.005. Epub 2014 , Feb 17. PMID:24556575 doi:http://dx.doi.org/10.1016/j.jsb.2014.02.005

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OCA

[1] Halter T, Imkampe J, Mazzotta S, Wierzba M, Postel S, Bucherl C, Kiefer C, Stahl M, Chinchilla D, Wang X, Nurnberger T, Zipfel C, Clouse S, Borst JW, Boeren S, de Vries SC, Tax F, Kemmerling B. The leucine-rich repeat receptor kinase BIR2 is a negative regulator of BAK1 in plant immunity. Curr Biol. 2014 Jan 20;24(2):134-43. doi: 10.1016/j.cub.2013.11.047. Epub 2014, Jan 2. PMID:24388849 doi:http://dx.doi.org/10.1016/j.cub.2013.11.047

[2] Blaum BS, Mazzotta S, Noldeke ER, Halter T, Madlung J, Kemmerling B, Stehle T. Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis. J Struct Biol. 2014 Apr;186(1):112-21. doi: 10.1016/j.jsb.2014.02.005. Epub 2014 , Feb 17. PMID:24556575 doi:http://dx.doi.org/10.1016/j.jsb.2014.02.005

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