Crystal structure of two-domain RSV INTEGRASE covalently linked with DNACrystal structure of two-domain RSV INTEGRASE covalently linked with DNA

Structural highlights

4fw1 is a 2 chain structure with sequence from Rous sarcoma virus - Prague C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.86Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

POL_RSVP Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).

See Also

4fw1, resolution 1.86Å

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OCA