Crystal structure of the substrate binding domain of E.coli DnaK in complex with PR-39 (residues 1 to 15)Crystal structure of the substrate binding domain of E.coli DnaK in complex with PR-39 (residues 1 to 15)

Structural highlights

4ezo is a 4 chain structure with sequence from Escherichia coli K-12 and Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DNAK_ECOLI Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]

See Also

4ezo, resolution 1.90Å

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