3pug

Haloferax volcanii Malate Synthase Native at 3mM GlyoxylateHaloferax volcanii Malate Synthase Native at 3mM Glyoxylate

Structural highlights

3pug is a 1 chain structure with sequence from Haloferax volcanii DS2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACEB_HALVD Involved in the glyoxylate cycle which synthesizes precursors for carbohydrates from C2 compounds such as acetate. Catalyzes the Claisen condensation between acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form the malyl-CoA intermediate that is subsequently hydrolyzed to produce malate and CoA.^[1] ^[2] ^[3]

References

↑ Serrano JA, Bonete MJ. Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii. Biochim Biophys Acta. 2001 Aug 30;1520(2):154-62. PMID:11513957
↑ Bracken CD, Neighbor AM, Lamlenn KK, Thomas GC, Schubert HL, Whitby FG, Howard BR. Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G. BMC Struct Biol. 2011 May 10;11(1):23. PMID:21569248 doi:10.1186/1472-6807-11-23
↑ Serrano JA, Camacho M, Bonete MJ. Operation of glyoxylate cycle in halophilic archaea: presence of malate synthase and isocitrate lyase in Haloferax volcanii. FEBS Lett. 1998 Aug 28;434(1-2):13-6. PMID:9738442

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OCA

[1] Serrano JA, Bonete MJ. Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii. Biochim Biophys Acta. 2001 Aug 30;1520(2):154-62. PMID:11513957

[2] Bracken CD, Neighbor AM, Lamlenn KK, Thomas GC, Schubert HL, Whitby FG, Howard BR. Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G. BMC Struct Biol. 2011 May 10;11(1):23. PMID:21569248 doi:10.1186/1472-6807-11-23

[3] Serrano JA, Camacho M, Bonete MJ. Operation of glyoxylate cycle in halophilic archaea: presence of malate synthase and isocitrate lyase in Haloferax volcanii. FEBS Lett. 1998 Aug 28;434(1-2):13-6. PMID:9738442

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