3j4r

Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopyPseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy

3j4r, resolution 35.00Å Show:Asymmetric Unit Biological Assembly Structural highlights 3j4r is a 5 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 35Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function AKA7G_RAT Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). Isoform Delta may be involved in shuttling aquaporin-2 (AQP2) to the plasma membrane.[UniProtKB:Q9P0M2] See Also A-kinase anchor protein 3D structures CAMP-dependent protein kinase 3D structures