3bs7
Crystal structure of the Sterile Alpha Motif (SAM) domain of Hyphen/AveugleCrystal structure of the Sterile Alpha Motif (SAM) domain of Hyphen/Aveugle
Structural highlights
FunctionAVE_DROME Required for normal photoreceptor differentiation between Ras and Raf for EGFR signaling in the eye and for mitogen-activated protein kinase phosphorylation. Probably acts together with Cnk to promote Raf activation, perhaps by recruiting an activating kinase. Evolutionary ConservationCheck, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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