Crystal structure of isomaltase from Saccharomyces cerevisiaeCrystal structure of isomaltase from Saccharomyces cerevisiae
Structural highlights
3a47 is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
MALX3_YEAST Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization. Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides. Does not hydrolyze maltose.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Yamamoto K, Nakayama A, Yamamoto Y, Tabata S. Val216 decides the substrate specificity of alpha-glucosidase in Saccharomyces cerevisiae. Eur J Biochem. 2004 Aug;271(16):3414-20. PMID:15291818 doi:10.1111/j.1432-1033.2004.04276.x
↑Teste MA, Francois JM, Parrou JL. Characterization of a new multigene family encoding isomaltases in the yeast Saccharomyces cerevisiae, the IMA family. J Biol Chem. 2010 Aug 27;285(35):26815-24. doi: 10.1074/jbc.M110.145946. Epub, 2010 Jun 18. PMID:20562106 doi:10.1074/jbc.M110.145946
