2wq7

Structure of the 6-4 photolyase of D. melanogaster in complex with the non-natural N4-methyl T(6-4)C lesionStructure of the 6-4 photolyase of D. melanogaster in complex with the non-natural N4-methyl T(6-4)C lesion

Structural highlights

2wq7 is a 3 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8SXK5_DROME

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Repair of the Dewar valence isomers by (6-4) photolyases proceeds via an enzyme catalyzed ring-opening reaction of the Dewar lesion to the (6-4) photoproduct.

DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions.,Glas AF, Kaya E, Schneider S, Heil K, Fazio D, Maul MJ, Carell T J Am Chem Soc. 2010 Feb 18. PMID:20166732^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Glas AF, Kaya E, Schneider S, Heil K, Fazio D, Maul MJ, Carell T. DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions. J Am Chem Soc. 2010 Feb 18. PMID:20166732 doi:10.1021/ja910917f

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OCA

[1] Glas AF, Kaya E, Schneider S, Heil K, Fazio D, Maul MJ, Carell T. DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions. J Am Chem Soc. 2010 Feb 18. PMID:20166732 doi:10.1021/ja910917f

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