2qym

crystal structure of unliganded PDE4C2crystal structure of unliganded PDE4C2

2qym is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

PDE4C_HUMAN Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.^[1] ^[2]

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

↑ Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem J. 2007 Dec 1;408(2):193-201. PMID:17727341 doi:http://dx.doi.org/10.1042/BJ20070970
↑ Engels P, Sullivan M, Müller T, Lübbert H. Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). FEBS Lett. 1995 Jan 30;358(3):305-10. PMID:7843419 doi:10.1016/0014-5793(94)01460-i