Catalytic Domain of Human Calpain 8Catalytic Domain of Human Calpain 8
Structural highlights
2nqa is a 4 chain structure with sequence from Homo sapiens and Streptomyces roseus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
CAN2_HUMAN Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.CAN8_HUMAN Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
