2n7q

Structure of the transmembrane domain of human nicastrin in SDS micellesStructure of the transmembrane domain of human nicastrin in SDS micelles

Structural highlights

2n7q is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

NICA_HUMAN Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry.

Function

NICA_HUMAN Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

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OCA