2kax

Solution structure and dynamics of S100A5 in the apo and Ca2+ -bound statesSolution structure and dynamics of S100A5 in the apo and Ca2+ -bound states

Structural highlights

2kax is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

S10A5_HUMAN Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Schafer BW, Fritschy JM, Murmann P, Troxler H, Durussel I, Heizmann CW, Cox JA. Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. J Biol Chem. 2000 Sep 29;275(39):30623-30. PMID:10882717 doi:http://dx.doi.org/10.1074/jbc.M002260200

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OCA

[1] Schafer BW, Fritschy JM, Murmann P, Troxler H, Durussel I, Heizmann CW, Cox JA. Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. J Biol Chem. 2000 Sep 29;275(39):30623-30. PMID:10882717 doi:http://dx.doi.org/10.1074/jbc.M002260200

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