2fr7

Crystal Structure of Cytochrome P450 CYP199A2Crystal Structure of Cytochrome P450 CYP199A2

Structural highlights

2fr7 is a 1 chain structure with sequence from Rhodopseudomonas palustris CGA009. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.01Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CYPA2_RHOPA The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4-ethylbenzoate.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Bell SG, Hoskins N, Xu F, Caprotti D, Rao Z, Wong LL. Cytochrome P450 enzymes from the metabolically diverse bacterium Rhodopseudomonas palustris. Biochem Biophys Res Commun. 2006 Mar 31;342(1):191-6. doi:, 10.1016/j.bbrc.2006.01.133. Epub 2006 Feb 3. PMID:16472768 doi:http://dx.doi.org/10.1016/j.bbrc.2006.01.133
↑ Bell SG, Xu F, Forward I, Bartlam M, Rao Z, Wong LL. Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris. J Mol Biol. 2008 Nov 14;383(3):561-74. Epub 2008 Aug 22. PMID:18762195 doi:10.1016/j.jmb.2008.08.033

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OCA

[1] Bell SG, Hoskins N, Xu F, Caprotti D, Rao Z, Wong LL. Cytochrome P450 enzymes from the metabolically diverse bacterium Rhodopseudomonas palustris. Biochem Biophys Res Commun. 2006 Mar 31;342(1):191-6. doi:, 10.1016/j.bbrc.2006.01.133. Epub 2006 Feb 3. PMID:16472768 doi:http://dx.doi.org/10.1016/j.bbrc.2006.01.133

[2] Bell SG, Xu F, Forward I, Bartlam M, Rao Z, Wong LL. Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris. J Mol Biol. 2008 Nov 14;383(3):561-74. Epub 2008 Aug 22. PMID:18762195 doi:10.1016/j.jmb.2008.08.033

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