2c47

Structure of casein kinase 1 gamma 2Structure of casein kinase 1 gamma 2

Structural highlights

2c47 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KC1G2_HUMAN Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.^[1] ^[2] ^[3] ^[4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Yinan M, Yu Q, Zhiyue C, Jianjun L, Lie H, Liping Z, Jianhui Z, Fang S, Dingfang B, Qing L, Xiru W. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. Neurosci Lett. 2004 Sep 16;368(1):2-6. PMID:15342122 doi:http://dx.doi.org/10.1016/j.neulet.2004.06.054
↑ Mishra SK, Yang Z, Mazumdar A, Talukder AH, Larose L, Kumar R. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9. PMID:15077195 doi:http://dx.doi.org/10.1038/sj.onc.1207569
↑ Guo X, Waddell DS, Wang W, Wang Z, Liberati NT, Yong S, Liu X, Wang XF. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. Oncogene. 2008 Dec 11;27(58):7235-47. doi: 10.1038/onc.2008.337. Epub 2008 Sep, 15. PMID:18794808 doi:http://dx.doi.org/10.1038/onc.2008.337
↑ Tomishige N, Kumagai K, Kusuda J, Nishijima M, Hanada K. Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell. 2009 Jan;20(1):348-57. doi: 10.1091/mbc.E08-07-0669. Epub 2008 Nov, 12. PMID:19005213 doi:http://dx.doi.org/10.1091/mbc.E08-07-0669

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OCA

[1] Yinan M, Yu Q, Zhiyue C, Jianjun L, Lie H, Liping Z, Jianhui Z, Fang S, Dingfang B, Qing L, Xiru W. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. Neurosci Lett. 2004 Sep 16;368(1):2-6. PMID:15342122 doi:http://dx.doi.org/10.1016/j.neulet.2004.06.054

[2] Mishra SK, Yang Z, Mazumdar A, Talukder AH, Larose L, Kumar R. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9. PMID:15077195 doi:http://dx.doi.org/10.1038/sj.onc.1207569

[3] Guo X, Waddell DS, Wang W, Wang Z, Liberati NT, Yong S, Liu X, Wang XF. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. Oncogene. 2008 Dec 11;27(58):7235-47. doi: 10.1038/onc.2008.337. Epub 2008 Sep, 15. PMID:18794808 doi:http://dx.doi.org/10.1038/onc.2008.337

[4] Tomishige N, Kumagai K, Kusuda J, Nishijima M, Hanada K. Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell. 2009 Jan;20(1):348-57. doi: 10.1091/mbc.E08-07-0669. Epub 2008 Nov, 12. PMID:19005213 doi:http://dx.doi.org/10.1091/mbc.E08-07-0669

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