Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

THEORETICAL MODEL OF THE AI5G GROUP II INTRONTHEORETICAL MODEL OF THE AI5G GROUP II INTRON

Structural highlights

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Publication Abstract from PubMed

Despite the biological importance of self-splicing group II introns, little is known about their structural organization. Synthetic incorporation of site-specific photo-cross-linkers within catalytic domains resulted in functional distance constraints that, when combined with known tertiary interactions, provide a three-dimensional view of the active intron architecture. All functionalities important for both steps of splicing are proximal before the first step, suggestive of a single active-site region for group II intron catalysis.

A single active-site region for a group II intron.,de Lencastre A, Hamill S, Pyle AM Nat Struct Mol Biol. 2005 Jul;12(7):626-7. Epub 2005 Jun 26. PMID:15980867[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. de Lencastre A, Hamill S, Pyle AM. A single active-site region for a group II intron. Nat Struct Mol Biol. 2005 Jul;12(7):626-7. Epub 2005 Jun 26. PMID:15980867 doi:10.1038/nsmb957
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