Crystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDPCrystal Structure of GDP-mannose 4,6-dehydratase ternary complex with NADPH and GDP
Structural highlights
1n7h is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
GMD2_ARATH Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Bonin CP, Potter I, Vanzin GF, Reiter WD. The MUR1 gene of Arabidopsis thaliana encodes an isoform of GDP-D-mannose-4,6-dehydratase, catalyzing the first step in the de novo synthesis of GDP-L-fucose. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2085-90. PMID:9050909
↑Bonin CP, Freshour G, Hahn MG, Vanzin GF, Reiter WD. The GMD1 and GMD2 genes of Arabidopsis encode isoforms of GDP-D-mannose 4,6-dehydratase with cell type-specific expression patterns. Plant Physiol. 2003 Jun;132(2):883-92. Epub 2003 May 15. PMID:12805618 doi:http://dx.doi.org/10.1104/pp.103.022368
