ULTRA HIGH RESOLUTION CRYSTAL STRUCTURE OF TEM-1ULTRA HIGH RESOLUTION CRYSTAL STRUCTURE OF TEM-1
Structural highlights
1m40 is a 1 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1l7u. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
BLAT_ECOLX TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
