1b9w
C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI
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OverviewOverview
The C-terminal proteolytic processing product of merozoite surface protein, 1 (MSP1) appears essential for successful erythrocyte invasion by the, malarial parasite, Plasmodium. We have determined the crystal structure at, 1.8 A resolution of a soluble baculovirus-recombinant form of the protein, from P. cynomolgi, which confers excellent protective efficacy in primate, vaccination trials. The structure comprises two EGF-like domains, and, sequence comparisons strongly suggest that the same conformation is, present in all species of Plasmodium, including P. falciparum and P., vivax, which are pathogenic in man. In particular, conserved interdomain, contacts between the two EGF modules should preserve the compact form of, the molecule in all species. Implications of the crystal structure for, anti-malarial vaccine development are discussed.
About this StructureAbout this Structure
1B9W is a Single protein structure of sequence from Plasmodium cynomolgi. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate., Chitarra V, Holm I, Bentley GA, Petres S, Longacre S, Mol Cell. 1999 Apr;3(4):457-64. PMID:10230398
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