2zm4

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Template:STRUCTURE 2zm4

File:2zm4.png

Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)

Template:ABSTRACT PUBMED 18977146

DiseaseDisease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this StructureAbout this Structure

2ZM4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase., Ozawa T, Tsuji E, Ozawa M, Handa C, Mukaiyama H, Nishimura T, Kobayashi S, Okazaki K, Bioorg Med Chem. 2008 Dec 15;16(24):10311-8. Epub 2008 Oct 22. PMID:18977146 [[Category: Pdbx_ordinal=, <PDBx:audit_author.]]

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