1ln6

OverviewOverview

The structural changes that accompany activation of a G-protein coupled, receptor (GPCR) are not well understood. To better understand the, activation of rhodopsin, the GPCR responsible for visual transduction, we, report studies on the three-dimensional structure for the activated state, of this receptor, metarhodopsin II. Differences between the, three-dimensional structure of ground state rhodopsin and metarhodopsin, II, particularly in the cytoplasmic face of the receptor, suggest how the, receptor is activated to couple with transducin. In particular, activation, opens a groove on the surface of the receptor that could bind the, N-terminal helix of the G protein, transducin alpha.

About this StructureAbout this Structure

1LN6 is a Single protein structure of sequence from [1] with RET as ligand. Full crystallographic information is available from OCA.

ReferenceReference

Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin., Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL, Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:12044163

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