1l2q
Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)
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OverviewOverview
Genes encoding methanogenic methylamine methyltransferases all contain an, in-frame amber (UAG) codon that is read through during translation. We, have identified the UAG-encoded residue in a 1.55 angstrom resolution, structure of the Methanosarcina barkeri monomethylamine methyltransferase, (MtmB). This structure reveals a homohexamer comprised of individual, subunits with a TIM barrel fold. The electron density for the UAG-encoded, residue is distinct from any of the 21 natural amino acids. Instead it, appears consistent with a lysine in amide-linkage to, (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino, acid be named l-pyrrolysine.
About this StructureAbout this Structure
1L2Q is a Single protein structure of sequence from Methanosarcina barkeri with NH4, X7O and BGX as ligands. Full crystallographic information is available from OCA.
ReferenceReference
A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:12029132
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