2fji
Crystal structure of the C-terminal domain of the exocyst subunit Sec6p
OverviewOverview
The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite <10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.
About this StructureAbout this Structure
2FJI is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles., Sivaram MV, Furgason ML, Brewer DN, Munson M, Nat Struct Mol Biol. 2006 Jun;13(6):555-6. Epub 2006 May 14. PMID:16699513 Page seeded by OCA on Sun May 4 03:58:20 2008