Signal recognition particle receptor

Signal recognition particle receptor (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the signal recognition particle (SRP). SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called FtsY. See also Intracellular receptors . Water molecules are shown as red spheres. .

spinqualitylabelsall models Human SRPR α (magenta) and β subunit (deepskyblue) complex with GTP and Mg+2 (green) ion 2fh5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of signal recognition particle receptor3D structures of signal recognition particle receptor

Signal recognition particle receptor 3D structures

Updated on 20-November-2023

{"openlevels":0}

• Signal recognition particle receptor
  • 2fh5 - hSRPR α+β subunits + GTP – human
    
  • 6y32 - hSRPR α subunit + SRP54 + GNP
    
  • 5l3q - hSRPR α subunit + SRP54 + AMP + GNP
    
  • 2go5 - hSRPR α subunit + mSRPR β subunit + ribosomal proteins L23, L31, L35 + dSRP19 + dSRP54 + RNA - Cryo EM
    
  • 7obq - rSRPR α+b subunits + dSRP19 + dSRP54 + dSRP68 + dSRP72 + RNA – rabbit - Cryo EM
    
  • 7nfx - rSRPR α+b subunits in human ribosome - Cryo EM
    
  • 1nrj – ySRPR α+β subunits + GTP – yeast
    
  • 2ged - ySRPR β subunit (mutant)
    
• Signal recognition particle receptor FtsY; Domain NG 195-498
  • 3jaj, 3jan – FtsY in ribosome - rabbit - Cryo EM
    
  • 5l3r – SRPR FtsY + SRP54 - Arabidopsis thaliana
    
  • 1zu5, 1zu4 – SRPR FtsY NG domain – Mycoplasma mycoides
    
  • 1vma – SRPR FtsY – Thermotoga maritima
    
  • 6cy1 – EaSRPR FtsY – Elizabethkingia anopheles
    
  • 6cy5 – EaSRPR FtsY NG domain + GDP
    
  • 2q9a – TaSRPR FtsY – Thermus aquaticus
    
  • 2q9c, 2q9b – TaSRPR FtsY NG domain + GMPPNP
    
  • 2j7p, 1rj9, 1okk – TaSRPR FtsY NG domain + SRP
    
  • 2cnw – TaSRPR FtsY NG domain + SRP + GDP
    
  • 5niy – EcSRPR FtsY – Escherichia coli
    
  • 6fpk, 6fpr – EcSRPR FtsY N-terminal
    
  • 2yhs, 2qy9, 1fts, 6cqp, 6cs8, 6n5i, 6n5j, 6n6n, 6n9b, 6nc1, 6nc4 – EcSRPR FtsY NG domain
    
  • 6fqd – EcSRPR FtsY NG domain + GDP
    
  • 7o9h – EcSRPR FtsY NG domain + pppGpp
    
  • 6c58, 6cvd, 6dlx – EcSRPR FtsY NG domain + antibiotic
    
  • 2iyl – EcSRPR FtsY residues 20-303 + GDP
    
  • 2xxa - EcSRPR FtsY NG domain + SRP residues 1-433 (mutant) + 4.5SRNA
    
  • 3zn8 - EcSRPR FtsY NG domain + SRP54 NG domain + 4.5SRNA + dipeptidyl aminopeptidase B
    
  • 4c7o – EcFtsY + EcSRP + SRP RNA
    
  • 2xkv – EcFtsY + EcSRP NG+M domains + 4.5S RNA
    
  • 5aka, 5gad, 5nco, 5gaf, 5gag, 5gah – EcFtsY in ribosome - Cryo EM
    
  • 5l3w – SRPR FtsY NG domain - Sulfolobus acidocaldarius
    
  • 5l3s – SRPR FtsY + SRP54 + GNP - Sulfolobus solfataricus
    
  • 3dm9, 3dmd, 3e70 – SRPR + GDP – Pyrococcus furiosus

</StructureSection>