6cn0

2.95 Angstrom Crystal Structure of 16S rRNA Methylase from Proteus mirabilis2.95 Angstrom Crystal Structure of 16S rRNA Methylase from Proteus mirabilis

Structural highlights

6cn0 is a 4 chain structure with sequence from Proteus mirabilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.95Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RMTC_PROMI Specifically methylates the N(7) position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin and kanamycin.^[1] ^[2]

References

↑ Wachino J, Yamane K, Shibayama K, Kurokawa H, Shibata N, Suzuki S, Doi Y, Kimura K, Ike Y, Arakawa Y. Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides. Antimicrob Agents Chemother. 2006 Jan;50(1):178-84. doi:, 10.1128/AAC.50.1.178-184.2006. PMID:16377684 doi:http://dx.doi.org/10.1128/AAC.50.1.178-184.2006
↑ Wachino J, Shibayama K, Kimura K, Yamane K, Suzuki S, Arakawa Y. RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms. FEMS Microbiol Lett. 2010 Oct;311(1):56-60. doi:, 10.1111/j.1574-6968.2010.02068.x. Epub 2010 Aug 16. PMID:20722735 doi:http://dx.doi.org/10.1111/j.1574-6968.2010.02068.x

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OCA

[1] Wachino J, Yamane K, Shibayama K, Kurokawa H, Shibata N, Suzuki S, Doi Y, Kimura K, Ike Y, Arakawa Y. Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides. Antimicrob Agents Chemother. 2006 Jan;50(1):178-84. doi:, 10.1128/AAC.50.1.178-184.2006. PMID:16377684 doi:http://dx.doi.org/10.1128/AAC.50.1.178-184.2006

[2] Wachino J, Shibayama K, Kimura K, Yamane K, Suzuki S, Arakawa Y. RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms. FEMS Microbiol Lett. 2010 Oct;311(1):56-60. doi:, 10.1111/j.1574-6968.2010.02068.x. Epub 2010 Aug 16. PMID:20722735 doi:http://dx.doi.org/10.1111/j.1574-6968.2010.02068.x

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