6ap4

Crystal structure of the DNA polymerase III subunit beta from Acinetobacter baumanniiCrystal structure of the DNA polymerase III subunit beta from Acinetobacter baumannii

Structural highlights

6ap4 is a 16 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	6amq, 6ams
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[V5V7W3_ACIBA] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[PIRNR:PIRNR000804]

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