4kk2

Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structureCrystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure

Structural highlights

4kk2 is a 2 chain structure with sequence from Artsi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	FDS-5, FDS-1 (ARTSI)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.^[1]

References

↑ Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200

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OCA

[1] Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200

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