Interferon receptor

Interferon receptor (IFNR) is a cell surface receptor which binds interferon. Interferon α/β receptor binds interferon-α and interferon-β. It is a heterodimer with subunits INFAR1 and INFAR2. For more details see IFNAR Interferon γ receptor binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2. Interferon δ receptor binds interferon-δ. See also Insulin receptor (Hebrew).

spinqualitylabelsall models Structure of interferon α/β receptor β chain ectodomain (green and yellow) complex with interferon-α 2 (grey and pink) and Cl- ion (green) (PDB entry 3s9d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of interferon receptor3D structures of interferon receptor

Updated on 10-February-2016

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• Interferon α/β receptor
  • 3s98 – hINFAR1 ectodomain – human
    
  • 1n6u, 1n6v – hINFAR2 ectodomain - NMR
    
  • 3s8w – hINFAR2 D2 domain - NMR
    
  • 2hym, 2kz1, 2lag – hINFAR2 ectodomain + interferon-α 2 - NMR
    
  • 3s9d – hINFAR2 ectodomain + interferon-α 2
    
  • 3se3 – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-α 2
    
  • 3se4 – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-ω 1
    
  • 3wcy – INFAR1 ectodomain + interferon-β - mouse
    
• Interferon γ receptor
  • 1jrh – hINFGR1 N terminal (mutant) + antibody
    
  • 1fg9, 1fyh – hINFGR1 extracellular domain + interferon-γ
    
  • 4eq2, 4eq3 – INFGR1 α chain - chicken
    
• Interferon δ receptor
  • 3og4, 3og6 – hINFDR1 extracellular domain + interleukin-29