User:Yunlong Zhao/Sandbox 1

IntroductionIntroduction

Antithrombin and thrombin interactions play an important role in multiple functions. Interestingly, an heparin or polysaccharides can regulate the function of antithrombin to different signaling. ^[1]

Heparin Binding site on antithrombin

Green scene 1 will be a antithrombin specific site for binding heparin

Green scene 2 will be the complex with heparin

The mechanism of heparin regulating antithrombin thrombin interaction

Green scene 1 will be the interface between AT and thrombin

Green scene 2 will be the the interface structure plus heparin

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

ReferencesReferences

↑ Johnson DJ, Huntington JA. Crystal structure of antithrombin in a heparin-bound intermediate state. Biochemistry. 2003 Jul 29;42(29):8712-9. PMID:12873131 doi:10.1021/bi034524y

[1] Johnson DJ, Huntington JA. Crystal structure of antithrombin in a heparin-bound intermediate state. Biochemistry. 2003 Jul 29;42(29):8712-9. PMID:12873131 doi:10.1021/bi034524y

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