4py0

Crystal structure of P2Y12 receptor in complex with 2MeSATPCrystal structure of P2Y12 receptor in complex with 2MeSATP

Structural highlights

4py0 is a 1 chain structure. Full crystallographic information is available from OCA.
Ligands:	,
Related:	4ntj, 4pxz
Activity:	Glucokinase, with EC number 2.7.1.2
Resources:	FirstGlance, OCA, RCSB, PDBsum

Disease

[P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.

Function

[P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.

References

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OCA