3d9f
Nitroalkane oxidase: active site mutant S276A crystallized with 1-nitrohexaneNitroalkane oxidase: active site mutant S276A crystallized with 1-nitrohexane
FunctionFunction
[NAO_FUSOX] Catalyzes the oxidative denitrification of neutral nitroalkanes, including 3-nitro-2-pentanol, 1-nitropropane, 2-nitropropane, nitroethane and nitrocyclohexane, and may thereby protect the organism against toxic compounds. Has no detectable acyl-CoA dehydrogenase activity.[1] [2] [3]
About this StructureAbout this Structure
3d9f is a 4 chain structure with sequence from Fusox. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Heroux A, Bozinovski DM, Valley MP, Fitzpatrick PF, Orville AM. Crystal Structures of Intermediates in the Nitroalkane Oxidase Reaction (dagger) (double dagger). Biochemistry. 2009 Mar 27. PMID:19265437 doi:10.1021/bi8023042
- ↑ Daubner SC, Gadda G, Valley MP, Fitzpatrick PF. Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2702-7. Epub 2002 Feb 26. PMID:11867731 doi:http://dx.doi.org/10.1073/pnas.052527799
- ↑ Kido T, Hashizume K, Soda K. Purification and properties of nitroalkane oxidase from Fusarium oxysporum. J Bacteriol. 1978 Jan;133(1):53-8. PMID:22538
- ↑ Nagpal A, Valley MP, Fitzpatrick PF, Orville AM. Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnover. Biochemistry. 2006 Jan 31;45(4):1138-50. PMID:16430210 doi:10.1021/bi051966w