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3k3h

Revision as of 09:33, 13 November 2013 by OCA (talk | contribs)

Template:STRUCTURE 3k3h

Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691

Template:ABSTRACT PUBMED 20121115

FunctionFunction

[PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.[1]

About this StructureAbout this Structure

3k3h is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis. J Med Chem. 2010 Feb 1. PMID:20121115 doi:10.1021/jm901519f
  1. ↑ Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:18757755

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