1of5

OverviewOverview

The association between Mtr2 and Mex67 is essential for the nuclear export, of bulk messenger RNA in yeast. In metazoans, the analogous function is, carried out by the TAP-p15 heterodimer. Whereas Mex67 and TAP are highly, conserved proteins, their binding partners, Mtr2 and p15, share no, sequence similarity, but are nevertheless functionally homologous. Here, we report the 2.8-A resolution crystal structure of Mtr2 in complex with, the NTF2-like domain of Mex67. Mtr2 is a novel member of the NTF2-like, family and interacts with Mex67, forming a complex with a similar, structural architecture to that of TAP-p15. Mtr2 fulfils an analogous, function to that of human p15 in maintaining the structural integrity of, the heterodimer. In addition, Mtr2 presents a long internal loop, which, ... [(full description)]

About this StructureAbout this Structure

1OF5 is a [Protein complex] structure of sequences from [Saccharomyces cerevisiae] with HG as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

ReferenceReference

Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15., Fribourg S, Conti E, EMBO Rep. 2003 Jul;4(7):699-703. PMID:12835756

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