1dq8

Ligands:

, ,

Activity:

Structural annotation:
Resources:	CATH : 1Dq8A03, 1Dq8A02, 1Dq8A01, 1Dq8B02, 1Dq8B01, 1Dq8B03, 1Dq8C02, 1Dq8C01, 1Dq8C03, 1Dq8D03, 1Dq8D02, 1Dq8D01 InterPro : Ipr009023, Ipr000731, Ipr002202, Ipr004816, Ipr004554, Ipr009029 Pfam : PF00368 SCOP : d1dq8a4, d1dq8a1, d1dq8b4, d1dq8b1, d1dq8c1, d1dq8c4, d1dq8d1, d1dq8d4 UniProt : P04035

Functional annotation:
Cellular component:	membrane fraction endoplasmic reticulum endoplasmic reticulum membrane membrane peroxisome integral to membrane
Biological process:	germ cell migration lipid metabolic process cholesterol biosynthetic process gonad development sterol biosynthetic process cholesterol metabolic process lipid biosynthetic process biosynthetic process steroid biosynthetic process
Molecular function:	oxidoreductase activity hydroxymethylglutaryl-CoA reductase (NADPH) activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

About this StructureAbout this Structure

1dq8 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

↑ Istvan ES, Palnitkar M, Buchanan SK, Deisenhofer J. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J. 2000 Mar 1;19(5):819-30. PMID:10698924 doi:10.1093/emboj/19.5.819