Proteopedia

3gnv

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Template:STRUCTURE 3gnv

File:3gnv.png

HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1bHCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b

Template:ABSTRACT PUBMED 19507864

About this StructureAbout this Structure

3gnv is a 2 chain structure with sequence from Hepatitis c virus isolate hc-j4. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Vandyck K, Cummings MD, Nyanguile O, Boutton CW, Vendeville S, McGowan D, Devogelaere B, Amssoms K, Last S, Rombauts K, Tahri A, Lory P, Hu L, Beauchamp DA, Simmen K, Raboisson P. Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase. J Med Chem. 2009 Jul 23;52(14):4099-102. PMID:19507864 doi:10.1021/jm9005548

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