1ial

OverviewOverview

Importin alpha is the nuclear import receptor that recognizes classical, monopartite and bipartite nuclear localization signals (NLSs). The, structure of mouse importin alpha has been determined at 2.5 A resolution., The structure shows a large C-terminal domain containing armadillo, repeats, and a less structured N-terminal importin beta-binding domain, containing an internal NLS bound to the NLS-binding site. The structure, explains the regulatory switch between the cytoplasmic, high-affinity, form, and the nuclear, low-affinity form for NLS binding of the nuclear, import receptor predicted by the current models of nuclear import., Importin beta conceivably converts the low- to high-affinity form by, binding to a site overlapping the autoinhibitory sequence. The structure, also has ... [(full description)]

About this StructureAbout this Structure

1IAL is a [Single protein] structure of sequence from [Mus musculus]. Structure known Active Site: AIS. Full crystallographic information is available from [OCA].

ReferenceReference

Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha., Kobe B, Nat Struct Biol. 1999 Apr;6(4):388-97. PMID:10201409

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