2dxs
Crystal structure of HCV NS5B RNA polymerase complexed with a tetracyclic inhibitor
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OverviewOverview
We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors, containing a conformationally constrained tetracyclic scaffold. SAR, studies led to the identification of, 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing, a basic pendent group with high biochemical and cellular potencies. These, compounds displayed a very small shift in cellular potency when the, replicon assay was performed in the presence of human serum albumin.
About this StructureAbout this Structure
2DXS is a Single protein structure of sequence from Hepatitis c virus with as ligand. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
ReferenceReference
Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors., Ikegashira K, Oka T, Hirashima S, Noji S, Yamanaka H, Hara Y, Adachi T, Tsuruha J, Doi S, Hase Y, Noguchi T, Ando I, Ogura N, Ikeda S, Hashimoto H, J Med Chem. 2006 Nov 30;49(24):6950-3. PMID:17125247
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