1s12

OverviewOverview

The crystal structure of a hypothetical protein, TM1457, from Thermotoga, maritima has been determined at 2.0A resolution. TM1457 belongs to the, DUF464 family (57 members) for which there is no known function. The, structure shows that it is composed of two helices in contact with one, side of a five-stranded beta-sheet. Two identical monomers form a, pseudo-dimer in the asymmetric unit. There is a large cleft between the, first alpha-helix and the second beta-strand. This cleft may be, functionally important, since the two highly conserved motifs, GHA and, VCAXV(S/T), are located around the cleft. A structural comparison of, TM1457 with known protein structures shows the best hit with another, hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they, share low structural similarity. Therefore, TM1457 still retains a unique, topology and reveals a novel fold.

About this StructureAbout this Structure

1S12 is a Single protein structure of sequence from Thermotoga maritima with as ligand. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:16242963

Page seeded by OCA on Wed Jan 23 15:23:13 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA