1lpi
HEW LYSOZYME: TRP...NA CATION-PI INTERACTION
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OverviewOverview
Experimental evidence of a cation-pi interaction between a sodium cation, (Na+) and the indole ring of residue Trp123 in a structure (2.0 A) of hen, egg-white lysozyme is presented. The geometry of the metal ion-pi, interaction observed in the protein structure (distance between the, aromatic plane and the cation approximately 4 A) is consistent with, geometries observed among small molecules crystal structures and quantum, chemistry ab initio calculations. The present crystal structure of, lysozyme provides unique structural information about the geometry of, binding of cations to pi systems in proteins. It shows that the metal, ion-pi interaction within proteins is not significantly different from, similar bindings found in small molecules and that it can be modeled by, theoretical ... [(full description)]
About this StructureAbout this Structure
1LPI is a [Single protein] structure of sequence from [Gallus gallus] with NA as [ligand]. Active as [Lysozyme], with EC number [3.2.1.17]. Structure known Active Site: PON. Full crystallographic information is available from [OCA].
ReferenceReference
Cation-pi (Na+-Trp) interactions in the crystal structure of tetragonal lysozyme., Wouters J, Protein Sci. 1998 Nov;7(11):2472-5. PMID:9828016
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