1hsg

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

Template:ABSTRACT PUBMED 7929352

File:1hsg.png

1hsg, resolution 2.00Å ()

Ligands:

Gene:

HIV-1 PROTEASE FROM THE NY5 ISOLATE (Human immunodeficiency virus 1)

Structural annotation:
Resources:	CATH : 1Hsga00, 1Hsgb00 InterPro : Ipr010659, Ipr010999, Ipr001995, Ipr008916, Ipr010661, Ipr002156, Ipr001878, Ipr000071, Ipr000721, Ipr012337, Ipr001037, Ipr009007, Ipr001969, Ipr008919, Ipr003308, Ipr000477, Ipr013084, Ipr001584 Pfam : PF00077 SCOP : d1hsga_, d1hsgb_ UniProt : P03367

Functional annotation:
Cellular component:	cytoplasm viral nucleocapsid nucleus membrane viral capsid virion
Biological process:	viral reproduction viral procapsid maturation DNA integration proteolysis DNA recombination RNA-dependent DNA replication transposition, DNA-mediated
Molecular function:	hydrolase activity nucleotidyltransferase activity ribonuclease H activity nucleic acid binding aspartic-type endopeptidase activity peptidase activity endonuclease activity DNA binding transferase activity RNA-directed DNA polymerase activity metal ion binding structural molecule activity RNA binding magnesium ion binding DNA-directed DNA polymerase activity zinc ion binding nuclease activity catalytic activity integrase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASESCRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES

About this StructureAbout this Structure

1HSG is a 2 chains structure with sequences from Human immunodeficiency virus 1. The June 2000 RCSB PDB Molecule of the Month feature on HIV-1 Protease by David S. Goodsell is 10.2210/rcsb_pdb/mom_2000_6. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC. Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J Biol Chem. 1994 Oct 21;269(42):26344-8. PMID:7929352

Page seeded by OCA on Thu Jan 21 08:33:19 2010

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC. Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J Biol Chem. 1994 Oct 21;269(42):26344-8. PMID:7929352

[xtra 1]